Next Generation Products Predicted to Have No Potential to Induce Developmental Toxicity in the devTOX quickPredict Assay
Presented by Imperial Brands at the British Toxicology Society Annual Congress, in Cambridge, UK (April, 2019)
This study compared the potential developmental toxicity of NGP aerosols to cigarette smoke using Stemina’s devTOX quickPredict human pluripotent stem cell-based assay. This assay uses the metabolic perturbation of the biomarkers ornithine/cystine ratio (o/c ratio) to predict developmental toxicity potential.
There is a growing scientific consensus that next generation products (NGPs) present a less harmful alternative to cigarettes for adult smokers. However, further research is required to adequately assess if NGP aerosols present a developmental risk to the unborn foetus.
The results add to the weight-of-evidence indicating that the test NGPs are likely to be less harmful than cigarettes.
