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Developmental Toxicity Potency of Valproate Analogues in a Human Pluripotent Stem Cell-Based Assay -[Northland Chapter of SOT, 2017 – Slides]

September 28, 2017 in /by

Presented at the Annual Meeting of the Northland Chapter of the Society of Toxicology (September 2017) by Jessica Palmer, Associate Director of Toxicology.

Development and validation of alternative models for developmental toxicity testing is essential for reducing the number of animals used for toxicity testing. While replacing animal models has been at the forefront of the toxicology field for over a decade…

EU-ToxRisk Case Study: Developmental Toxicity Potency of Valproate Analogues in Human Pluripotent Stem Cell-Based Assay [WC-10 (2017)]

August 23, 2017 in /by

Presented at the 10th World Congress on Alternatives and Animal Use in the Life Sciences in Seattle, August 2017, by Stemina’s Associate Director of Toxicology, Jessica Palmer.

The development and use of alternative models of safety screening in place of animal models has been at the forefront of the toxicology field for over a decade; however, application of these assays in a regular setting is still poorly understood…

Prediction of Developmental Toxicity Potential Dictated by In Vivo Exposures with a Biomarker-Based Human Pluripotent Stem Cell Assay – [Teratology Society 2017 – Slides]

June 26, 2017 in /by

Presented at the Teratology Society’s 57th Annual Meeting in Denver, Colorado in June 2017 by Stemina’s Associate Director of Toxicology, Jessica Palmer.

Previous approaches for evaluating the accuracy of alternative test methods have been based on the classification of a chemical as either a positive or negative, with no other distinction…

Comparative Retrospective Analysis of In Vivo and In Vitro Developmental Toxicity Predictions [SOT 2017]

March 14, 2017 in /by

Presented at the Society of Toxicology’s Annual Meeting & ToxExpo in Baltimore, March 2017, by Stemina’s Associate Director of Toxicology, Jessica Palmer.

Development and validation of in vitro models for developmental toxicity testing is essential for reducing the number of animals used toxicity testing. These assays have the potential to reduce or replace animal use in chemical safety testing for multiple industries, as well as to support ongoing worldwide…