Prediction of Developmental Toxicity Potential Dictated by In Vivo Exposures with a Biomarker-Based Human Pluripotent Stem Cell Assay – [Teratology Society 2017 – Slides]
Presented at the Teratology Society’s 57th Annual Meeting in Denver, Colorado in June 2017 by Stemina’s Associate Director of Toxicology, Jessica Palmer.
Previous approaches for evaluating the accuracy of alternative test methods have been based on the classification of a chemical as either a positive or negative, with no other distinction. This method does not mimic the in vivo situation, where a chemical is positive or negative in the context of dose level.
The devTOX quickPredict assay was designed around the premise that manifestation of developmental toxicity is dependent to a large degree on chemical dose.
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