In Vitro to In Vivo Extrapolation for Developmental Toxicity Potency of Valproic Acid Analogue [ASCCT 2020]
Presented by Jessica Palmer at the American Society for Cellular and Computational Toxicology (October, 2020)
Abstract
- Previous work showed that the potency ranking from devTOXqP assay was consistent with in vivo developmental toxicity potency, but whether the assay could quantitatively predict in vivo exposure exerting developmental toxicity was unknown.
- In this study, in vitro to in vivo extrapolation (IVIVE) was performed to predict the in vivo developmental toxicity dose levels by estimating equivalent administered doses (EADs) that would result in maternal and/or fetal blood concentrations equivalent to the developmental toxicity potential (dTP) concentrations derived from the devTOXqP assay (Figure 1).The impact of pharmacokinetics and different modeling approaches on EAD prediction was also evaluated.
