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devTOX quickPredictTM Accurately Predicts the Developmental Toxicity Potential of the ICH S5(R3) Guideline Reference Compounds [BDRP, 2022]

Presented by Jessica Palmer at the Society for Birth Defects and Research Meeting; June, 2022

There have been increased efforts in the pharmaceutical and chemical industries to incorporate new approach methods (NAMs) in vitro,, ex vivo, or in silico) earlier in the product development pipeline prior to in vivo testing.

A Targeted Metabolomics-Based Assay Using Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Identifies Structural and Functional Cardiotoxicity Potential [WC11, 2021]

Presented by Jessica Palmer at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; August, 2021

Implementing screening assays that identify functional and structural cardiotoxicity earlier in the drug development pipeline has the potential to improve safety and the cost and time required to bring new drugs to market.

Defining the Reproducibility and Applicability Domain of devTOX quickPredictTM, a Human Pluripotent Stem Cell-Based Developmental Toxicity Assay [WC11, 2021]

Presented by Jessica Palmer at the 11th World Congress on Alternatives and Animal Use in the Life Sciences; August, 2021

Assessing the accuracy, reproducibility, and applicability domain of new approach methods (NAMs) is necessary step for establishing confidence in these methods and enabling their use in a regulatory setting.

A Human Pluripotent Stem Cell-Based Assay, devTOX quickPredictTM, Accurately and Reproducibly Predicts the Developmental Toxicity Potential Across a Diverse Set of Chemicals [SOT, 2021]

Presented by Jessica Palmer at the Society for Toxicology Meeting; March, 2021

Tyrosine kinase inhibitors (TKI) have greatly improved the treatment and prognosis for a wide range of cancers. Unfortunately, numerous TKIs produce cardiotoxic effects, which were not well predicted during preclinical studies.