Accurate prediction of functional and structural cardiotoxicity
Cardio quickPredictTM IS 86% PREDICTIVE OF CARDITOXICITY
In a recent study, we exposed iPSC-derived cardiomyocytes to 81 compounds and analyzed the spent media using UPLC-HRMS-based metabolomics. Cardiotoxicity potential was predicted based on changes in five metabolites and cell viability.
Balanced Accuracy | 86% |
Sensitivity | 83% |
Specificity | 90% |
PPV | 93% |
NPV | 74% |
Functional Accuracy* | 93% |
Structural Accuracy* | 63% |
“General” Accuracy* | 90% |
*Percent of Subclass Correctly Predicted at Cardiotoxic
Cardio quickPredictTM Results Interpretation
- Prediction of cardiotoxicity is based on a composite model containing three biomarker ratios.
- The assay identifies the exposure levelwhere a test compound that alters metabolism at a level indicative of cardiotoxicity.
- Cardiotoxicity Threshold: Level of change in the ratios associated with cardiotoxicity.
- Cardiotoxicity Potential Concentration: Test compound concentration predicted to be associated with cardiotoxicity.
How it Works
CardioqP TM uses iCell® Cardiomyocytes2
Courtesy of Cellular Dynamics International, a FUJIFILM company.
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