Entries by

In Vitro to In Vivo Extrapolation for Developmental Toxicity Potency of Valproic Acid Analogues [ASCCT, 2020]

Presented by Jessica Palmer at the American Society for Cellular and Computational Toxicology; October, 2020

Previous work showed that the potency ranking from devTOXqP assay was consistent with in vivo developmental toxicity potency, but whether the assay could quantitatively predict in vivo exposure exerting developmental toxicity was unknown.

Biomarker-Based Prediction of Tyrosine Kinase Inhibitor Cardiotoxicity using Human iPSC-Derived Cardiomyocytes [SPSM, 2019]

Presented by Jessica Palmer at the Safety Pharmacology Society Meeting in Barcelona, Spain; September, 2019

Tyrosine kinase inhibitors (TKI) have greatly improved the treatment and prognosis for a wide range of cancers. Unfortunately, numerous TKIs produce cardiotoxic effects, which were not well predicted during preclinical studies.

Predicting Tyrosine Kinase Inhibitor Cardiotoxicity with a Biomarker-Based Human iPSC-Derived Cardiomyocyte Assay [SOT, 2019]

Presented at the Society of Toxicology Annual Meeting and ToxExpo in Baltimore, Maryland; March 2019.

Tyrosine kinase inhibitors (TKI) have greatly improved the treatment and prognosis for a wide range of cancers but often cause cardiotoxic effects. We developed an in vitro assay, Cardio quickPredict, for predicting cardiovascular liability based on changes in human iPSC-derived cardiomyocytes (iPSC-CM) metabolism and cell viability, which identifies both functional and structural cardiotoxicants.