Cardio quickPredict: A New Way to Evaluate Cardiotoxicity Potential [SOT 2018 – Presentation Slides]

Presented at the Society of Toxicology Annual Meeting and ToxEXPO in San Antonio, Texas, March 2018 by Stemina’s Associate Director of Toxicology, Jessica Palmer.Predicting cardiotoxicity remains a challenge. Cardiovascular toxicity is a major cause leading to compound attrition throughout the drug discovery and development process as well as withdrawal of FDA-approved drugs from the market…

Development of an In Vitro Assay to Predict Cardiotoxicity Potential Using Targeted Metabolomics and Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes [SOT 2018]

Presented at the Society of Toxicology Annual Meeting and ToxEXPO in San Antonio, Texas, March 2018, by Stemina’s Associate Director of Toxicology, Jessica Palmer.

Cardiac safety is one of the leading causes of late-stage compound attrition in the pharmaceutical industry and accounts for 28% of the safety-related withdrawals of FDA-approved drugs from the market. Metabolic perturbations are one of the primary mechanisms of cardiotoxicity elicited by pharmaceuticals…

Use of Alternative Developmental Toxicity Assays Under ICH S5 and devTOX quickPredict – Webinar [March 8, 2018 – Recording, Slides]