A Human Pluripotent Stem Cell-Based Assay Accurately Predicts the Developmental Toxicity Potency for a Series of Valproate Analogues [Teratology Society 2018]

Presented at the Teratology Society Annual Meeting in Clearwater, Florida; June 2018

Regulatory acceptance of alternative methods for toxicity testing remains a challenge despite international efforts to reduce animal use. Multiple agencies are working to develop a framework to implement the use of new approach methodologies for assessing the effects of chemical exposure on human health. In this study, we report the results from the devTOX quickPredictTM platform on eight valproate analogues included in the EU-ToxRisk case study. The results provide a human-relevant endpoint that could inform chemical prioritization and risk assessment.