Supporting Read-Across Using Biological Data [ALTEX, 2015]
Read-across, i.e., filling toxicological data gaps by relating to similar chemicals for which test data are available, is usually done based on chemical similarity. Besides structure and physico-chemical properties, biological similarity based on biological data adds extra strength to this process. In the simplest case, chemically similar substances also show similar test results in relevant in vitro assays. Stemina authors include Elizabeth Donley and Jessica Palmer.
Supporting Read-Across Using Biological Data