Toward Good Read-Across Practice (GRAP) Guidance [ALTEX, 2016]
Grouping of substances and utilizing read-across of data within those groups represents an important data gap filling technique for chemical safety assessments. Categories/analogue groups are typically developed based on structural similarity and, increasingly often, also on mechanistic (biological) similarity. While read-across can play a key role in complying with legislation such as the European REACH regulation, the lack of consensus regarding the extent and type of evidence necessary to support it often hampers its successful application and acceptance by regulatory authorities. Stemina authors include Elizabeth Donley and Jessica Palmer.
Toward Good Read-Across Practice (GRAP) Guidance
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